Table of Contents
- The sarcomeric cytoskeleton: from molecules to motion
Summary: The sarcomeric cytoskeleton is a system of proteins specific to striated muscle that play a key role in organising the contractile machinery, and integrating and regulating its mechanics and signalling functions.
- Non-crossbridge stiffness in active muscle fibres
Summary: This review summarizes the current knowledge regarding static stiffness, from its identification by our group, to the present, and evaluates the role of titin as the structure possibly responsible for this non-crossbridge stiffness.
MECHANISMS OF MUSCLE CONTRACTION AND EXCITATION-CONTRACTION COUPLING
- Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin
Summary: The underlying molecular basis of genetic-based cardiomyopathy diseases is largely unknown. This review describes recent molecular studies that have used human cardiac proteins to begin to elucidate the mechanisms whereby mutations cause disease.
- Myosin isoforms and the mechanochemical cross-bridge cycle
Summary: Mammals express more than 11 different muscle myosin isoforms. Studies of different isoforms and the effect of mutations in these isoforms illustrate how myosin is adapted for specific functions.
- Bridging the myoplasmic gap II: more recent advances in skeletal muscle excitation–contraction coupling
Summary: This article reviews recent work regarding the communication between the L-type Ca2+ channel (CaV1.1) and the type 1 ryanodine receptor (RyR1) that supports excitation–contraction coupling in skeletal muscle.
- Skeletal muscle tissue in movement and health: positives and negatives
Summary: The mechanics and energetics of muscles doing work (shortening) are better understood than those of muscles being stretched while active. Recent evidence suggests the elastic titin filament plays a key role.
- Eccentric contraction: unraveling mechanisms of force enhancement and energy conservation
Summary: This review suggests novel mechanisms for muscle eccentric contraction based on interactions among myosin, actin and titin.
- Neural control of lengthening contractions
Summary: The neural control of lengthening contraction differs from that of shortening or isometric contractions; current knowledge on the specific control of lengthening contractions is summarized.
- Molecular networks in skeletal muscle plasticity
Summary: A comprehensive review of the current state of research on the molecular networks that regulate skeletal muscle phenotypic plasticity with different types of exercise, disuse, ageing and disease.
- Effects of skeletal muscle energy availability on protein turnover responses to exercise
Summary: Skeletal muscle adaptation to exercise training serves to blunt the homeostatic intracellular perturbations caused by accelerated energetic demands, and these responses are influenced by exogenous and endogenous energy availability.
- Skeletal muscle mass and composition during mammalian hibernation
Summary: Despite massive reductions in activity and nutrient intake during winter, hibernators largely preserve skeletal muscle. My review summarizes these data and explores potential mechanisms explaining this remarkable outcome.
- Muscle memory and a new cellular model for muscle atrophy and hypertrophy
Summary: New evidence indicates that during hypertrophy, pre-existing muscle fibres recruit nuclei from satellite cells, which are not lost during atrophy. The new permanent myonuclei represent cellular memory facilitating subsequent growth.
MUSCLE IN MOTION
- Contribution of elastic tissues to the mechanics and energetics of muscle function during movement
Summary: Muscles are full of springs. Some roles for elastic elements are well established; others can be predicted based on the potential for energy storage within individual elastic elements.
- Muscle structural assembly and functional consequences
Summary: This review explains the contribution of early renaissance studies on human anatomy and physiology to our current understanding of the contractile behaviour and adaptations of skeletal muscle to overloading, unloading and ageing.
- Locomotion as an emergent property of muscle contractile dynamics
Summary: The in vivo dynamics of muscle contractile function reflect the interplay of muscle–tendon architecture and neural activation timing relative to the forces and work that muscles produce to power locomotor movement.